A research filter, not a predictor — not financial advice. Grades rank growth stocks on evidence-based quality signals from end-of-day data; they are not buy/sell calls or price forecasts. Always do your own research.
Spyre Therapeutics, Inc. SYRE
Mixed (early) broader-coverage candidate · Spyre Therapeutics, Inc.
On FrontierLab's discovery record since 2026-07-10 (6 weeks ago) — when this name first surfaced. (distinct from the snapshot date below)
Auto-graded broader coverage — sourced by an automated screen and graded on default bands, not the sector-calibrated bands the curated screener uses. A "Mixed (early)" here is NOT the same bar as a curated grade; these are auto-screened candidates for your own research, shown as of their surface date (2026-08-19), not the curated Frontier signal.
Key quality signals
| Revenue growth (YoY) | — |
|---|---|
| Gross margin | 0% |
| Gross profits / assets | 0 |
| Rule of 40 | — |
| Net margin | -222.5% |
| Cash runway (months) | 65.8 |
| PEG | — |
| Price / sales | 103.5 |
Quality checklist
- ~ Capital efficiency
- ✗ Gross margin — 0% (pass ≥ 60%)
- ✓ Share dilution — 39.6%
Fundamentals — snapshot as of 2026-08-19
| Stage | Early |
|---|---|
| Share issuance (YoY) | 39.6% · heavy issuance |
| Moat | — |
| TAM | — |
| P/E (trailing) | — |
| EPS (trailing) | $-1.95 |
| Burn multiple | 2.3 |
| Gross-margin trend (pts) | — |
| Cash / assets | 0.98 |
| Net debt / EBITDA | — |
| Statements as of | Q2 FY2026 · filed 2026-08-04 |
Momentum context — a snapshot from 2026-08-19, not current
| Price at surface | $107.82 (as of 2026-08-19) |
|---|---|
| 52-week range | $14.505 – $108.62 |
| % off 52-wk high | -0.7% |
| RSI (14) | 61 |
| Relative volume | 1.2× |
Risk flags
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Data as of 2026-08-19 (end-of-day). How grades are computed →